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I have just uploaded my latest interview.

Living Longer and Healthier

The Most Promising Life Extension Drug

In this interview Ross Pelton discusses Rapamycin and autophagy. These were new terms for me. The story of Rapamycin is interesting and intriguing. Rapamycin is a drug that was developed after discovery on Easter Island led to the drug’s development. This is an example of how a natural compound in nature is discovered, researched and developed as a drug. Ross covers this discovery in this interview and in his newest book: RAPAMYCIN – The Most Promising Life Extension Drug. This was all new to me and Ross’ book is a powerful introduction.

What is autophagy?

“Autophagy (pronounced “ah-TAH-fah-gee”) is your body’s process of reusing old and damaged cell parts. Cells are the basic building blocks of every tissue and organ in your body. Each cell contains multiple parts that keep it functioning. Over time, these parts can become defective or stop working. They become litter, or junk, inside an otherwise healthy cell.

Autophagy is your body’s cellular recycling system. It allows a cell to disassemble its junk parts and repurpose the salvageable bits and pieces into new, usable cell parts. A cell can discard the parts it doesn’t need.

Autophagy is also quality control for your cells. Too many junk components in a cell take up space and can slow or prevent a cell from functioning correctly. Autophagy remakes the clutter into the selected cell components you need, optimizing your cells’ performance.” Source: ClevelandClinic.org

Here is a short excerpt from our interview:

Rapamycin is the name of the most promising life extension drug that’s ever been discovered. So 25 years or more of research have been conducted by scientists around the world trying to figure out the mechanisms of action. How does this drug do what it does? And so there are really two main themes in my book. One is the story of Rapamycin, which is in itself a very interesting story. But beyond the drug Rapamycin research into its mechanisms of action, have discovered what I think is an even more important story, which is the story of mTOR and autophagy. And I’ll get into a discussion of these terms and explain to our listeners what they mean.

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